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The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma

Received: 22 July 2019     Accepted: 28 August 2019     Published: 17 September 2019
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Abstract

Multiple trauma often causes acute kidney injury (AKI) and is one of the most common causes of death in the world. Multiple trauma is a severe injury to an organ that is followed or accompanied by injury to other organs with injury severity score ≥ 16 causing hypovolume, hypoxia, and the release of inflammatory mediators which may lead to AKI. The diagnosis of AKI has been carried out using serum creatinine but this examination has many shortcomings, especially in terms of the time of increase in serum creatinine and much influenced by other factors. New biomarkers are expected to have an advantage over serum creatinine, namely kidney injury molecule-1 (KIM-1). This study aims to determine the area under curve (AUC) and the accuracy of KIM-1 for the diagnosis of AKI in polytrauma. This study carried out a diagnostic test using secondary data with a cross sectional design of all secondary data of the study. This study took secondary data from patients with multiple trauma at the emergency room at RSUP Dr. Hasan Sadikin Bandung from January - June 2017, which is the academic leadership grant (ALG) research data. Data was processed by diagnostic tests, and analyzed by receiver operating characteristic (ROC) curves. KIM-1 has a 109.7 ng / mL cut-off point, sensitivity of 100%, specificity of 88.89%, positive predictive value of 71.4%, negative predictive value of 100%, AUC value of 0.857 and accuracy of 91.3%. The conclusion of this study is that biomarkers of KIM-1 have an AUC value and a good value of accuracy so that it can be used to diagnose AKI more accurately.

Published in Science Journal of Clinical Medicine (Volume 8, Issue 5)
DOI 10.11648/j.sjcm.20190805.11
Page(s) 49-53
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Acute Kidney Injury, Multiple Trauma, Creatinine, Kidney Injury Molecule–1

References
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[2] Butcher, NE, Balogh ZJ. Update on the definition of polytrauma. J Trauma Acute Care Surg. 2014; 70 (1): 107-11.
[3] Abreu KLS, Junior GB, Barreto AG, Melo FM, Oliveira BB. Acute kidney injury after trauma: Prevalence, clinical characteristics and RIFLE classification. Indian J Crit Care Med. 2010; 14: 121-8.
[4] Molitoris BA, Melnikov VY, Okusa MD, Himmelfarb J. Technology insight: Biomarker development in acute kidney injury – What can we anticipate? Nat Clin Pract Nephrol. 2008; 4 (3): 154-65.
[5] De Geus HR, Betjes MJ, Bakker J. Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges. Clin Kidney J. 2012; 5: 102-8.
[6] Rinawati W, Aulia D. Kidney injury molecule-1 (KIM-1) sebagai penanda baru nekrosis tubular akut. Artikel Khusus, Maj Kedokt Indon. 2011; 61 (2).
[7] Sabbisetti VS, Waikar SS, Antoine DJ, Smiles A, Wang C. Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes. J Am Soc Nephrol. 2014; 25 (10): 2177-86.
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[9] Oktaviana Firma. Pola cedera kecelakaan lalu lintas pada kendaraan beroda dua. [diunduh 22 November 2012]; Tersedia dari www.lontar.ui.ac.id/file?fileS-5384-Pola%20cidera-Bibliografi.pdf.
[10] Surgical Critical Care. Injury severity score; 2015. [diunduh 20 Agustus 2017]. Tersedia dari: http://www.surgicalcriticalcare.net.
[11] Campion HR. Trauma scoring. Scand Surg. 2012; 91: 12-22.
[12] Bagshaw SM, George C, Gibney RTN, Bellomo R. A multi-center evaluation of early acute kidney injury in critical ill trauma patients. Renal Failure. 2008; 30: 581-89.
[13] Rizvi MS, Kashani KB. Biomarkers for early detection of acute kidney injury. JALM. 2017; 02 (03): 386–99.
[14] Lombi F, Muryan A, Canzonier R, Trimarchi H. Biomarkers in acute kidney injury: Evidence or paradigm? Nefrologia. 2016; 36 (4): 339-46.
[15] Lawang SA, Pudjiadi A, Latief A. Neutropil gelatinase associated lipocalin urin sebagai deteksi dini AKI. Sari Pediatri. 2014; 16 (3) 195-200.
[16] Brady HR, Brenner BM. Acute Renal Failure. Dalam: Dennis LK, Anthony SF, Dan LL, Eugene B, Stephen LH, Larry J, penyunting. Harrison’s Principles of Internal Medicine. Edisi ke-18. New York: McGraw; 2013. hlm. 954-959.
[17] Maskoen TT, Suwarman, Masthura A. Nilai AUC dan akurasi NGAL untuk diagnosis AKI pada pasien politrauma di IGD RSHS. Anesth Crit Care. 2017; 35 (3): 158-64.
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Cite This Article
  • APA Style

    Tinni Trihartini Maskoen, Budiana Rismawan, Rangga Saputra. (2019). The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma. Science Journal of Clinical Medicine, 8(5), 49-53. https://doi.org/10.11648/j.sjcm.20190805.11

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    ACS Style

    Tinni Trihartini Maskoen; Budiana Rismawan; Rangga Saputra. The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma. Sci. J. Clin. Med. 2019, 8(5), 49-53. doi: 10.11648/j.sjcm.20190805.11

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    AMA Style

    Tinni Trihartini Maskoen, Budiana Rismawan, Rangga Saputra. The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma. Sci J Clin Med. 2019;8(5):49-53. doi: 10.11648/j.sjcm.20190805.11

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  • @article{10.11648/j.sjcm.20190805.11,
      author = {Tinni Trihartini Maskoen and Budiana Rismawan and Rangga Saputra},
      title = {The Accuracy of Kidney Injury Molecule- 1 for Earlier Diagnosis Acute Kidney Injury in Polytrauma},
      journal = {Science Journal of Clinical Medicine},
      volume = {8},
      number = {5},
      pages = {49-53},
      doi = {10.11648/j.sjcm.20190805.11},
      url = {https://doi.org/10.11648/j.sjcm.20190805.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20190805.11},
      abstract = {Multiple trauma often causes acute kidney injury (AKI) and is one of the most common causes of death in the world. Multiple trauma is a severe injury to an organ that is followed or accompanied by injury to other organs with injury severity score ≥ 16 causing hypovolume, hypoxia, and the release of inflammatory mediators which may lead to AKI. The diagnosis of AKI has been carried out using serum creatinine but this examination has many shortcomings, especially in terms of the time of increase in serum creatinine and much influenced by other factors. New biomarkers are expected to have an advantage over serum creatinine, namely kidney injury molecule-1 (KIM-1). This study aims to determine the area under curve (AUC) and the accuracy of KIM-1 for the diagnosis of AKI in polytrauma. This study carried out a diagnostic test using secondary data with a cross sectional design of all secondary data of the study. This study took secondary data from patients with multiple trauma at the emergency room at RSUP Dr. Hasan Sadikin Bandung from January - June 2017, which is the academic leadership grant (ALG) research data. Data was processed by diagnostic tests, and analyzed by receiver operating characteristic (ROC) curves. KIM-1 has a 109.7 ng / mL cut-off point, sensitivity of 100%, specificity of 88.89%, positive predictive value of 71.4%, negative predictive value of 100%, AUC value of 0.857 and accuracy of 91.3%. The conclusion of this study is that biomarkers of KIM-1 have an AUC value and a good value of accuracy so that it can be used to diagnose AKI more accurately.},
     year = {2019}
    }
    

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  • TY  - JOUR
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    AU  - Tinni Trihartini Maskoen
    AU  - Budiana Rismawan
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    AB  - Multiple trauma often causes acute kidney injury (AKI) and is one of the most common causes of death in the world. Multiple trauma is a severe injury to an organ that is followed or accompanied by injury to other organs with injury severity score ≥ 16 causing hypovolume, hypoxia, and the release of inflammatory mediators which may lead to AKI. The diagnosis of AKI has been carried out using serum creatinine but this examination has many shortcomings, especially in terms of the time of increase in serum creatinine and much influenced by other factors. New biomarkers are expected to have an advantage over serum creatinine, namely kidney injury molecule-1 (KIM-1). This study aims to determine the area under curve (AUC) and the accuracy of KIM-1 for the diagnosis of AKI in polytrauma. This study carried out a diagnostic test using secondary data with a cross sectional design of all secondary data of the study. This study took secondary data from patients with multiple trauma at the emergency room at RSUP Dr. Hasan Sadikin Bandung from January - June 2017, which is the academic leadership grant (ALG) research data. Data was processed by diagnostic tests, and analyzed by receiver operating characteristic (ROC) curves. KIM-1 has a 109.7 ng / mL cut-off point, sensitivity of 100%, specificity of 88.89%, positive predictive value of 71.4%, negative predictive value of 100%, AUC value of 0.857 and accuracy of 91.3%. The conclusion of this study is that biomarkers of KIM-1 have an AUC value and a good value of accuracy so that it can be used to diagnose AKI more accurately.
    VL  - 8
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Author Information
  • Department of Anesthesiology and Intensive Therapy, Faculty of Medicine Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia

  • Department of Anesthesiology and Intensive Therapy, Faculty of Medicine Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia

  • Department of Anesthesiology and Intensive Therapy, Faculty of Medicine Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, West Java, Indonesia

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